منابع مشابه
Cardiac epinephrine synthesis and ischemia-induced myocardial epinephrine release.
OBJECTIVE Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart. Ischemia evokes an excessive NE accumulation in the myocardial interstitial spaces. Therefore, cardiac PNMT activity with high NE levels may contribute to cardiac EPI synthesis and release evoke...
متن کاملVasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation.
BACKGROUND During the administration of advanced cardiac life support for resuscitation from cardiac arrest, a combination of vasopressin and epinephrine may be more effective than epinephrine or vasopressin alone, but evidence is insufficient to make clinical recommendations. METHODS In a multicenter study, we randomly assigned adults with out-of-hospital cardiac arrest to receive successive...
متن کاملCardiac Epinephrine Synthesis
Background. The heart can synthesize epinephrine. Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine. The cardiac atrium contains primarily PNMT and the cardiac ventricle contains both PNMT and NMT. Methods and Results. Rats were given the glucocorticoid dexamet...
متن کاملRat renal epinephrine synthesis.
Rats that underwent adrenal demedullation had a 93% decrease in plasma epinephrine (E) levels, but did not decrease their renal E. Even further treatment with 6-hydroxydopamine and reserpine failed to lower renal E levels. Similarly, urine E levels failed to decrease after adrenal demedullation and renal denervation. There is a renal E-synthesizing enzyme that differs from adrenal phenylethanol...
متن کاملEpinephrine and Tissue Permeability *
In a previous publication3 it was shown that spinal transection is followed by a pronounced reduction of tissue permeability.' Since it is known that spinal reflex centers for the liberation of epinephrine are located in the thoracic segment of the splnal cord,4 and since Favilli reported a reduction in skin permeability after.epinephrine injections, the question arose as to whether the liberat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-95064-4